# AOD-9604 Reviews

> An indexed studio review of the AOD-9604 record — six human trials, two regulatory decisions, one quietly closed obesity programme.

## Pages

- [AOD-9604 Reviews — The hexadecapeptide record, indexed and reviewed](/index.md): An editorial review of AOD-9604: six METAOD human trials, a failed Phase IIb obesity endpoint (2007), preclinical rabbit-OA evidence, the December 2024 FDA PCAC decision, and WADA Section S2 status. Research-context only.
- [AOD-9604 reported effects and safety — what the record and research-use community say](/effects.md): AOD-9604 reported effects, safety cautions, and development history — the community layer labeled anecdotal, the clinical cautions cited to primary sources.
- [AOD-9604 Research Review — Mechanism, six METAOD trials, and the 2024 record](/research.md): A detailed review of the AOD-9604 research literature: β3-adrenergic mechanism, foundational Zucker-rat work, the six-trial Metabolic Pharmaceuticals programme (METAOD001-006), the failed Phase IIb pivotal, the rabbit knee-OA pivot, and the December 2024 FDA PCAC decision.
- [AOD-9604 Dosage Research — Doses, routes, and PK from the published record](/dosage.md): A research-context review of every dose and route that has appeared in AOD-9604 studies: preclinical rodent (500 μg/kg oral, IV, IP), Phase I IV escalation, Phase II oral, intra-articular rabbit OA, and the GRAS nutraceutical level. Not a dosing recommendation.
- [AOD-9604 FAQ — Common review questions, answered from the record](/faq.md): Answers to the most-asked literature-review questions about AOD-9604: does it work, why did the Phase IIb fail, what changed in 2024, WADA status, mechanism, safety, half-life, GRAS vs FDA approval, OA evidence.
- [AOD-9604 References — Full citation index](/references.md): Full citation index for AOD-9604 Reviews: peer-reviewed studies (Ng 2000, Heffernan 2001, Stier 2013, Moré & Kenley 2014, Kwon & Park 2015, Liao 2024), FDA PCAC 2024 materials, WADA Prohibited List, and the Drug Testing and Analysis detection-assay paper.
- [About AOD-9604 Reviews — Independent editorial publisher](/about.md): AOD-9604 Reviews is an independent editorial project that publishes summaries of the peer-reviewed research literature on AOD-9604. We are not a clinic, we do not sell any product, and the 'reviews' in our name refers to our editorial review of the published record.
- [Contact AOD-9604 Reviews — Editorial correspondence only](/contact.md): Contact form for editorial correspondence with AOD-9604 Reviews. We are not a clinic and we do not provide medical advice or product information.